epigenetics and chromatin impact factor

These “epigenetic marks” alter the structure of chromatin to influence gene expression. Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear … Differing breadths of genome coverage by histone marks can impact learning-induced transcription. However a more contemporaneous definition acknowledges that many of the mechanisms used to perpetuate epigenetic traits in dividing cells are utilized by neurons to control activity-dependent gene expression. Epigenetics choreographs the interface between genes and the environment of an individual. Primarily brought about via external and environmental influence, these modifications alter the activity and performance of a gene without changing the underlying DNA code. Chromatin states can influence transcription factor binding 54, and DNA sequence 74. In this chapter, we summarize recent progress in the determination of the effects of epigenetic … Effects of Environmental Pollutants on Human Reproductive Health and Epigenetic Modifications Conference scheduled on June 24-25, 2021 in June 2021 in Paris is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums. Jan. 2019. It is well established that DNA is the hereditary material of the cell, and yet for every rule, there is an exception. ), one of the best-known medicinal plants in China, has a dehiscent anther which physiologically work in pollination, however, the dehiscent anther always closes in response to darkness every day, and watering or raining every time. The Translational Neuroimmunology Conference: From Bench to Bedside and Back. His research interests include the synthesis and biological evaluation of new bioactive compounds, in particular, small molecule modulators of epigenetic targets. 1. Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Paris polyphylla var. Impact Factor: 5 12. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 4.960 ℹ Five-Year Impact Factor: 2019: 4.960 Special Journal Issues. Impact Factor: 4.112 (2019) Epigenomics welcomes unsolicited article proposals . Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. Recently, it was shown that histone H1 imposes a non-permissive chromatin configuration preventing replication origin assembly on somatic nuclei. Epigenetic research is concerned with heritable changes that do not change DNA sequence, but rather involve stable modifications of chromatin, DNA or protein conformation, and includes research on non-coding RNAs, nuclear organization and chromatin interactions. 4 ). Chromatin To gain an understanding of epigenetic mechanisms, it is essential to first understand the role of chromatin in gene transcription. It is one of the leading journals in the field, with an impact factor over 3. Epigenetics and Chromatin IS is increased by a factor of 0.5 and approximate percentage change is 11.74% when compared to preceding year 2019, which shows a rising trend. Epigenomics Journal, Journal of Genetics & Epigenetics, Epigenetics & Chromatin and Epigenetics Journal. Epigenetics provides the critical connection between environmental influence and gene expression, where environmental stressors could modulate expression of specific genes in particular scenarios using molecular markers etched at the genome level. Cancer is a The proteins CTCF ( aka CCCTC-binding factor), mediator and cohesin are important components of the insulator complex that appear in distinct combinations depending on the range of interaction. Activation or silencing of these genes, determined by epigenetic mechanisms, seems to constitute an important regulator of synaptic potential and memory. Epigenetic Diagnosis & Therapy a peer-reviewed journal, publishes high-impact basic, translational, and clinical original research on epigenetic medicine. Obesity and cardiovascular diseases are rising (WHO, 2014) with the prevalence of obesity projecte… Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. The notion that the germ line does not age goes back to the 19th-century ideas of August Weismann. Genome-wide mapping of epigenetic marks led to the development of epigenomics, an emerging field that is expanding our ability to explain observed phenotypic variation through the identification of multiple cellular products such as RNAs, protein–DNA interactions, chromatin modifications, and chromatin accessibility (Lane et al., 2014). Epigenetic reprogramming during sperm development. Call for Papers: An epigenetic perspective of viral diseases, including SARS/MERS/COVID-19, Cancer and Autophagy. Cancer has been usually thought of as a genetic disease, but it is now known to be an epigenetic disease as well, caused by genetic alterations. Euchromatin corresponds, in general, to genome regions that possess actively transcribed genes (or potentially active ones), and that are decondensed during interphase. On the other hand, the training of models on all cell lines simultaneously generally improves the prediction. K. Sharma2, R. K. Phukan Epigenetics encompasses changes in DNA methylation, histone and chromatin structure, and non‑coding RNAs, specifically microRNA (miRNA) expression. Cell death & disease. A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity. Because epigenetic changes are reversible, epigenetic drugs can be used to modulate gene activity. Kung HJ, Changou CA, Li CF, Ann DK. Chromatophagy: autophagy goes nuclear and captures broken chromatin during arginine-starvation. One of the more recent study subjects is the 3D ‘spatial organization’ of the genome inside each and every nucleus of our brain cells, which is challenging old views. These pathways, coupled to regulated protein and RNA transport mechanisms, underpin the coordinated gene expression response. Epigenetics & Chromatin is a peer-reviewed, open access journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Dynamic shifts in chromatin states differentially mark the proliferative basal cells and terminally differentiated cells of the developing epidermis ... Epigenetics and epistasis at work for an ovarian phenotype. Although recently new insights into genes involved in NB have emerged, the molecular basis of neuroblastoma development and progression still remains poorly understood. The chromatin factors that influence the prediction most are stable across the cell lines, which suggests the universality of the biological mechanisms of TAD formation for two embryonic and one neuronal Drosophila cell line. Super-compaction of the genome may confer additional protection from the effects of genotoxic factors. The evidence suggests that epigenetic modifications within the CNS, crucial for behavioural adaptation in the short and long term, are the result of a variety of environmental stimuli.